"transmethylation" genre: Ambient Drum N' Bass
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	The transmethylation hypothesis in particular posited that serotonin could provide a substrate for the endogenous production of hallucinogens similar to N,N-dimethyltryptamine (DMT). Initially, this etiologically based model was dismissed because of the rapid tolerance associated with traditional hallucinogens such as LSD and mescaline. More recent studies indicating that tolerance may not occur to the subjective and behavioral effects of DMT in humans suggest that DMT may differ from other hallucinogens and that this model may still be viable. Indeed, different mechanisms may be involved in the various actions of the different hallucinogenic drugs, as suggested by the lack of cross-tolerance to DMT in human subjects made tolerant to LSD. Hence, further studies are warranted to provide the objective evidence needed to adequately evaluate the model of psychosis based on the hypothesis of an endogenous psychotogen.
	CD: oneirogen   Label: League of Surrealistic Discord Records

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